Insider Trading disclosures for Blueprint Medicines Corp

The latest disclosure was made by Christina Rossi in Blueprint Medicines Corp where a trade of 1,172 Common Stock done at an average price of $128.3 was reported to US exchanges on July 3, 2025.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 128.25 per share.	03 Jul 2025	1,172	63,546 (0%)	0%	128.3	150,309	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 128.25 per share.	03 Jul 2025	1,051	53,155 (0%)	0%	128.3	134,791	Common Stock
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	78,062 (0%)	0%	128.1	499,924	Common Stock
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	22,156 (0%)	0%	128.1	499,924	Common Stock
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	17,156 (0%)	0%	128.1	499,924	Common Stock
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	14,744 (0%)	0%	128.1	499,924	Common Stock
Jeffrey W. Albers	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	150,532 (0%)	0%	128.1	499,924	Common Stock
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 12812.00 per share.	18 Jun 2025	3,902	6,144 (0%)	0%	12812	49,992,424	Common Stock
Habib Joseph Dable	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	12,644 (0%)	0%	128.1	499,924	Common Stock
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 128.12 per share.	18 Jun 2025	3,902	12,644 (0%)	0%	128.1	499,924	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 127.88 per share.	03 Jun 2025	2,418	54,206 (0%)	0%	127.9	309,214	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 127.88 per share.	03 Jun 2025	241	56,624 (0%)	0%	127.9	30,819	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 101.02 per share.	27 May 2025	4,350	147,280 (0%)	0%	101.0	439,437	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2025	5,000	92,500	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 101.93 per share.	27 May 2025	650	146,630 (0%)	0%	101.9	66,255	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	27 May 2025	5,000	151,630 (0%)	0%	36.1	180,250	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 100.14 per share.	19 May 2025	804	66,188 (0%)	0%	100.1	80,513	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 100.67 per share.	19 May 2025	1,413	64,775 (0%)	0%	100.7	142,247	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 101.72 per share.	19 May 2025	57	64,718 (0%)	0%	101.7	5,798	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 103.56 per share.	05 May 2025	144	66,992 (0%)	0%	103.6	14,913	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 102.82 per share.	05 May 2025	180	67,136 (0%)	0%	102.8	18,508	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 101.77 per share.	05 May 2025	1,343	67,316 (0%)	0%	101.8	136,677	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 100.97 per share.	05 May 2025	607	68,659 (0%)	0%	101.0	61,289	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	05 May 2025	2,752	19,696 (0%)	0%	54.1	148,966	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 102.51 per share.	05 May 2025	1,252	18,444 (0%)	0%	102.5	128,343	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 May 2025	2,752	2,751	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 104.78 per share.	05 May 2025	100	16,944 (0%)	0%	104.8	10,478	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 103.57 per share.	05 May 2025	1,400	17,044 (0%)	0%	103.6	144,998	Common Stock
Kathryn Haviland	Director, CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 88.59 per share.	01 Apr 2025	100	165,929 (0%)	0%	88.6	8,859	Common Stock
Kathryn Haviland	Director, CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 87.34 per share.	01 Apr 2025	1,200	166,029 (0%)	0%	87.3	104,808	Common Stock
Kathryn Haviland	Director, CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 86.14 per share.	01 Apr 2025	598	167,229 (0%)	0%	86.1	51,512	Common Stock
Kathryn Haviland	Director, CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 85.47 per share.	01 Apr 2025	600	167,827 (0%)	0%	85.5	51,282	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 95.02 per share.	24 Mar 2025	2,274	69,266 (0%)	0%	95.0	216,075	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Mar 2025	7,500	97,500	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 88.37 per share.	12 Mar 2025	1,800	152,396 (0%)	0%	88.4	159,066	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 87.62 per share.	12 Mar 2025	5,700	154,196 (0%)	0%	87.6	499,434	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	12 Mar 2025	7,500	159,896 (0%)	0%	36.1	270,375	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	5,284	72,924 (0%)	0%	88.8	469,219	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	16,151	168,427 (0%)	0%	88.8	1,434,209	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	5,262	66,583 (0%)	0%	88.8	467,266	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	6,495	71,540 (0%)	0%	88.8	576,756	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	1,326	16,944 (0%)	0%	88.8	117,749	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	5,157	49,606 (0%)	0%	88.8	457,942	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	6,489	75,781 (0%)	0%	88.8	576,223	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	4,863	35,651 (0%)	0%	88.8	431,834	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 87.42 per share.	05 Mar 2025	2,691	32,960 (0%)	0%	87.4	235,247	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 87.98 per share.	05 Mar 2025	2,541	30,419 (0%)	0%	88.0	223,557	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	3,733	41,996 (0%)	0%	88.8	331,490	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	3,530	56,865 (0%)	0%	88.8	313,464	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 88.80 per share.	05 Mar 2025	5,766	146,630 (0%)	0%	88.8	512,021	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	78,208 (0%)	0%		0	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Option (Right to Buy)
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	70,400	70,400	-		-	Stock Option (Right to Buy)
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	35,200	184,578 (0%)	0%		0	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Option (Right to Buy)
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	71,845 (0%)	0%		0	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	13,200	78,035 (0%)	0%		0	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	26,400	26,400	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 89.63 per share.	01 Mar 2025	775	20,698 (0%)	0%	89.6	69,463	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	6,506	21,473 (0%)	0%		0	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	7,007	7,007	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 90.92 per share.	01 Mar 2025	238	20,460 (0%)	0%	90.9	21,639	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 93.42 per share.	01 Mar 2025	484	19,345 (0%)	0%	93.4	45,215	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 95.16 per share.	01 Mar 2025	1,075	18,270 (0%)	0%	95.2	102,297	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 92.00 per share.	01 Mar 2025	631	19,829 (0%)	0%	92	58,052	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	54,763 (0%)	0%		0	Common Stock
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	13,200	82,270 (0%)	0%		0	Common Stock
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	26,400	26,400	-		-	Stock Option (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	40,514 (0%)	0%		0	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Options (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	45,729 (0%)	0%		0	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Option (Right to Buy)
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	11,000	60,395 (0%)	0%		0	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2025	22,000	22,000	-		-	Stock Option (Right to Buy)
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 95.14 per share.	20 Feb 2025	2,274	64,835 (0%)	0%	95.1	216,348	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Jan 2025	10,000	105,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	21 Jan 2025	10,000	167,557 (0%)	0%	36.1	360,500	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 110.61 per share.	21 Jan 2025	200	152,396 (0%)	0%	110.6	22,122	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 109.92 per share.	21 Jan 2025	7,400	152,596 (0%)	0%	109.9	813,408	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 109.11 per share.	21 Jan 2025	7,561	159,996 (0%)	0%	109.1	824,981	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 110.24 per share.	21 Jan 2025	1,446	149,378 (0%)	0%	110.2	159,407	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 110.78 per share.	21 Jan 2025	808	67,230 (0%)	0%	110.8	89,510	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 108.99 per share.	21 Jan 2025	529	68,854 (0%)	0%	109.0	57,656	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 110.00 per share.	21 Jan 2025	816	68,038 (0%)	0%	110	89,760	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 111.81 per share.	21 Jan 2025	121	67,109 (0%)	0%	111.8	13,529	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	13 Jan 2025	5,000	162,557 (0%)	0%	36.1	180,250	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 102.28 per share.	13 Jan 2025	5,000	157,557 (0%)	0%	102.3	511,400	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Jan 2025	5,000	115,000	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	13 Jan 2025	2,250	17,217 (0%)	0%	36.1	81,113	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 100.00 per share.	13 Jan 2025	2,250	14,967 (0%)	0%	100	225,000	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Jan 2025	2,250	2,250	-		-	Stock Option (Right to Buy)
W. Jeffrey Albers	Director	Sale of securities on an exchange or to another person at price $ 91.15 per share.	19 Dec 2024	3,800	159,657 (0%)	0%	91.2	346,370	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 89.01 per share.	19 Dec 2024	5,180	163,457 (0%)	0%	89.0	461,072	Common Stock
Albers Jeffrey W.	Director	Sale of securities on an exchange or to another person at price $ 88.28 per share.	19 Dec 2024	3,920	168,637 (0%)	0%	88.3	346,058	Common Stock
Jeffrey Albers W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Dec 2024	15,000	120,000	-		-	Stock Option (Right to Buy)
Jeffrey Albers W.	Director	Sale of securities on an exchange or to another person at price $ 91.96 per share.	19 Dec 2024	2,100	157,557 (0%)	0%	92.0	193,116	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	19 Dec 2024	15,000	172,557 (0%)	0%	36.1	540,750	Common Stock
Rossi Christina	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 95.88 per share.	18 Dec 2024	2,166	69,491 (0%)	0%	95.9	207,676	Common Stock
Rossi Christina	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 96.50 per share.	18 Dec 2024	108	69,383 (0%)	0%	96.5	10,422	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	12 Dec 2024	1,600	16,786 (0%)	0%	15.0	24,016	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Dec 2024	1,600	0	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 93.99 per share.	12 Dec 2024	619	14,967 (0%)	0%	94.0	58,180	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 92.88 per share.	12 Dec 2024	1,200	15,586 (0%)	0%	92.9	111,456	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 97.76 per share.	29 Nov 2024	207	150,824 (0%)	0%	97.8	20,236	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 96.74 per share.	29 Nov 2024	1,746	151,031 (0%)	0%	96.7	168,908	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 95.40 per share.	29 Nov 2024	400	152,777 (0%)	0%	95.4	38,160	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 95.10 per share.	27 Nov 2024	2,274	71,657 (0%)	0%	95.1	216,257	Common Stock
Lonnel Coats	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 69.79 per share.	20 Nov 2024	7,500	20,754 (0%)	0%	69.8	523,425	Common Stock
Lonnel Coats	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Nov 2024	1,312	3,188	-		-	Stock Option (Right to Buy)
Lonnel Coats	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Nov 2024	7,500	0	-		-	Stock Option (Right to Buy)
Lonnel Coats	Director	Sale of securities on an exchange or to another person at price $ 94.87 per share.	20 Nov 2024	9,824	2,242 (0%)	0%	94.9	932,003	Common Stock
Lonnel Coats	Director	Sale of securities on an exchange or to another person at price $ 94.99 per share.	20 Nov 2024	213	12,066 (0%)	0%	95.0	20,233	Common Stock
Lonnel Coats	Director	Sale of securities on an exchange or to another person at price $ 94.24 per share.	20 Nov 2024	5,287	12,279 (0%)	0%	94.2	498,247	Common Stock
Lonnel Coats	Director	Sale of securities on an exchange or to another person at price $ 93.15 per share.	20 Nov 2024	4,500	17,566 (0%)	0%	93.2	419,175	Common Stock
Lonnel Coats	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 76.24 per share.	20 Nov 2024	1,312	22,066 (0%)	0%	76.2	100,027	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 102.00 per share.	07 Nov 2024	5,000	157,557 (0%)	0%	102	510,000	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Nov 2024	5,000	135,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	07 Nov 2024	5,000	162,557 (0%)	0%	36.1	180,250	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 89.32 per share.	03 Oct 2024	3,633	69,070 (0%)	0%	89.3	324,500	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Sep 2024	10,000	140,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 85.12 per share.	09 Sep 2024	7,734	157,557 (0%)	0%	85.1	658,318	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 85.86 per share.	09 Sep 2024	11,968	165,291 (0%)	0%	85.9	1,027,572	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	09 Sep 2024	10,000	177,259 (0%)	0%	36.1	360,500	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 95.23 per share.	15 Aug 2024	4,409	67,208 (0%)	0%	95.2	419,869	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	05 Aug 2024	157	34,886 (0%)	0%	36.1	5,660	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	12,350	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	10,572	6,928	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	8,450	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	4,331	20,669	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	5,011	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	1,042	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Aug 2024	157	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 93.19 per share.	05 Aug 2024	41,913	34,729 (0%)	0%	93.2	3,905,872	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.60 per share.	05 Aug 2024	12,350	76,642 (0%)	0%	86.6	1,069,510	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.31 per share.	05 Aug 2024	10,572	64,292 (0%)	0%	61.3	648,169	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	05 Aug 2024	8,450	53,720 (0%)	0%	54.1	457,399	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share.	05 Aug 2024	4,331	45,270 (0%)	0%	43.2	186,883	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.44 per share.	05 Aug 2024	5,011	40,939 (0%)	0%	81.4	408,096	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 51.06 per share.	05 Aug 2024	1,042	35,928 (0%)	0%	51.1	53,205	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	03 Jul 2024	3,850	47,613 (0%)	0%	54.1	208,401	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 111.29 per share.	03 Jul 2024	8,817	43,763 (0%)	0%	111.3	981,244	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	03 Jul 2024	8,817	52,580 (0%)	0%	54.1	477,264	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Jul 2024	3,850	0	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Jul 2024	8,817	3,850	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 111.20 per share.	03 Jul 2024	3,850	43,763 (0%)	0%	111.2	428,120	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2024	9,625	73,931 (0%)	0%		0	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2024	7,500	49,395 (0%)	0%		0	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Jun 2024	333	12,667	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 111.15 per share.	28 Jun 2024	333	43,763 (0%)	0%	111.2	37,013	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	28 Jun 2024	333	44,096 (0%)	0%	54.1	18,025	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share.	21 Jun 2024	13,741	71,056 (0%)	0%	18	247,338	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Jun 2024	15,500	13,000	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Jun 2024	24,200	0	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Jun 2024	7,041	0	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Jun 2024	13,471	0	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 102.44 per share.	21 Jun 2024	300	43,763 (0%)	0%	102.4	30,732	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 103.05 per share.	21 Jun 2024	13,062	44,063 (0%)	0%	103.0	1,346,039	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 104.14 per share.	21 Jun 2024	40,353	57,125 (0%)	0%	104.1	4,202,361	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 104.98 per share.	21 Jun 2024	18,752	97,478 (0%)	0%	105.0	1,968,585	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 105.82 per share.	21 Jun 2024	1,567	116,230 (0%)	0%	105.8	165,820	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	21 Jun 2024	15,500	117,797 (0%)	0%	54.1	839,015	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	21 Jun 2024	24,200	102,297 (0%)	0%	36.1	872,410	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share.	21 Jun 2024	7,041	78,097 (0%)	0%	18	126,738	Common Stock
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	74,160 (0%)	0%		0	Common Stock
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	18,254 (0%)	0%		0	Common Stock
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	13,254 (0%)	0%		0	Common Stock
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	10,842 (0%)	0%		0	Common Stock
Jeffrey W. Albers	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	167,259 (0%)	0%		0	Common Stock
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	13,254 (0%)	0%		0	Common Stock
Nicholas Lydon	Director		12 Jun 2024	2,242	58,026 (0%)	0%		0	Common Stock
Nicholas Lydon	Director		12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Habib Joseph Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Habib Joseph Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	8,742 (0%)	0%		0	Common Stock
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	2,242	8,742 (0%)	0%		0	Common Stock
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	4,570	4,570	-		-	Stock Option (Right to Buy)
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 105.13 per share.	05 Jun 2024	4,000	41,895 (0%)	0%	105.1	420,520	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 104.91 per share.	04 Jun 2024	2,424	29,514 (0%)	0%	104.9	254,302	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 106.43 per share.	03 Jun 2024	2,436	45,895 (0%)	0%	106.4	259,263	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.24 per share.	31 May 2024	10,573	56,854 (0%)	0%	66.2	700,356	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 May 2024	5,729	19,271	-		-	Stock Options (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 May 2024	8,385	9,115	-		-	Stock Options (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 May 2024	10,573	13,490	-		-	Stock Options (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 106.43 per share.	31 May 2024	1,951	31,938 (0%)	0%	106.4	207,645	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 106.43 per share.	31 May 2024	2,971	33,889 (0%)	0%	106.4	316,204	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 104.83 per share.	31 May 2024	6,342	36,860 (0%)	0%	104.8	664,832	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 105.81 per share.	31 May 2024	20,904	43,202 (0%)	0%	105.8	2,211,852	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 106.50 per share.	31 May 2024	3,191	64,106 (0%)	0%	106.5	339,842	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 107.86 per share.	31 May 2024	3,671	67,297 (0%)	0%	107.9	395,954	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share.	31 May 2024	5,729	70,968 (0%)	0%	43.1	247,206	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.31 per share.	31 May 2024	8,385	65,239 (0%)	0%	61.3	514,084	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 107.17 per share.	15 May 2024	2,486	72,981 (0%)	0%	107.2	266,425	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 106.56 per share.	15 May 2024	1,364	71,617 (0%)	0%	106.6	145,348	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2024	4,500	4,500	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 106.56 per share.	15 May 2024	2,274	14,913 (0%)	0%	106.6	242,317	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 107.22 per share.	15 May 2024	3,582	17,187 (0%)	0%	107.2	384,062	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.15 per share.	15 May 2024	1,356	20,769 (0%)	0%	43.1	58,511	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	15 May 2024	4,500	19,413 (0%)	0%	36.1	162,225	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2024	1,356	9,494	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share.	08 May 2024	1,818	75,467 (0%)	0%	8.8	15,998	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 May 2024	1,818	0	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 May 2024	26,363	0	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	08 May 2024	26,363	73,649 (0%)	0%	1.9	49,299	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 May 2024	10,000	0	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 105.00 per share.	02 May 2024	10,000	47,286 (0%)	0%	105	1,050,000	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	02 May 2024	10,000	57,286 (0%)	0%	36.1	360,500	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.13 per share.	02 May 2024	1,834	16,747 (0%)	0%	54.1	99,274	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 May 2024	1,843	5,503	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 103.88 per share.	02 May 2024	1,834	14,913 (0%)	0%	103.9	190,516	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	28 Mar 2024	5,000	52,286 (0%)	0%	36.1	180,250	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Mar 2024	5,000	10,000	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 95.00 per share.	28 Mar 2024	5,000	47,286 (0%)	0%	95	475,000	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	20 Mar 2024	15,073	191,123 (0%)	0%	1.9	28,187	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Mar 2024	10,000	0	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Mar 2024	15,073	0	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 89.12 per share.	20 Mar 2024	1,367	176,050 (0%)	0%	89.1	121,827	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 88.60 per share.	20 Mar 2024	6,285	177,417 (0%)	0%	88.6	556,851	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 87.26 per share.	20 Mar 2024	8,440	183,702 (0%)	0%	87.3	736,474	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 86.46 per share.	20 Mar 2024	6,251	192,142 (0%)	0%	86.5	540,461	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 85.22 per share.	20 Mar 2024	2,730	198,393 (0%)	0%	85.2	232,651	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	20 Mar 2024	10,000	201,123 (0%)	0%	15.0	150,100	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2024	5,000	15,000	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.08 per share.	15 Mar 2024	1,638	49,753 (0%)	0%	88.1	144,275	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 87.09 per share.	15 Mar 2024	4,629	51,391 (0%)	0%	87.1	403,140	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.88 per share.	15 Mar 2024	912	56,020 (0%)	0%	88.9	81,059	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.27 per share.	15 Mar 2024	1,413	56,932 (0%)	0%	88.3	124,726	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 87.10 per share.	15 Mar 2024	2,675	58,345 (0%)	0%	87.1	232,993	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	15 Mar 2024	5,000	61,020 (0%)	0%	36.1	180,250	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 88.94 per share.	15 Mar 2024	2,467	47,286 (0%)	0%	88.9	219,415	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 89.88 per share.	13 Mar 2024	1,800	34,729 (0%)	0%	89.9	161,784	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 90.55 per share.	13 Mar 2024	6,223	36,529 (0%)	0%	90.6	563,493	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	13 Mar 2024	1,224	42,752 (0%)	0%	15.0	18,372	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share.	13 Mar 2024	523	41,528 (0%)	0%	8.8	4,602	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	5,003	56,020 (0%)	0%	90.7	453,722	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	12,464	153,177 (0%)	0%	90.7	1,130,360	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	5,194	60,498 (0%)	0%	90.7	471,044	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		07 Mar 2024	2,521	33,853 (0%)	0%	90.7	228,629	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	6,070	64,306 (0%)	0%	90.7	550,488	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	1,462	17,862 (0%)	0%	90.7	132,589	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	5,093	57,585 (0%)	0%	90.7	461,884	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	4,377	72,703 (0%)	0%	90.7	396,950	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	3,097	46,281 (0%)	0%	90.7	280,867	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	2,934	41,005 (0%)	0%	90.7	266,084	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	2,286	48,331 (0%)	0%	90.7	207,317	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 90.69 per share.	07 Mar 2024	11,033	165,017 (0%)	0%	90.7	1,000,583	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		01 Mar 2024	12,500	36,995 (0%)	0%		0	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		01 Mar 2024	621	36,374 (0%)	0%	93.7	58,157	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	61,023 (0%)	0%		0	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	40,000	165,641 (0%)	0%		0	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	80,000	80,000	-		-	Stock Option (Right to Buy)
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	65,692 (0%)	0%		0	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	15,000	70,376 (0%)	0%		0	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	30,000	30,000	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	5,000	19,324 (0%)	0%		0	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	10,000	10,000	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	62,678 (0%)	0%		0	Common Stock
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	30,000	30,000	-		-	Stock Option (Right to Buy)
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	15,000	77,080 (0%)	0%		0	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Options (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	49,378 (0%)	0%		0	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	43,939 (0%)	0%		0	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	25,000	25,000	-		-	Stock Option (Right to Buy)
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2024	12,500	50,617 (0%)	0%		0	Common Stock
K. Christopher Murray	CHIEF TECHNICAL OPERATIONS		28 Feb 2024	5,000	8,000	-		-	Stock Option (Right to Buy)
K. Murray Christopher	CHIEF TECHNICAL OPERATIONS		28 Feb 2024	5,000	24,495 (0%)	0%	100	500,000	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		28 Feb 2024	5,000	29,495 (0%)	0%	54.1	270,650	Common Stock
Albers W. Jeffrey	Director	Sale of securities on an exchange or to another person at price $ 83.57 per share.	25 Jan 2024	100	176,050 (0%)	0%	83.6	8,357	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 81.70 per share.	25 Jan 2024	10,890	184,074 (0%)	0%	81.7	889,713	Common Stock
Jeffrey Albers W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jan 2024	15,000	15,073	-		-	Stock Option (Right to Buy)
Jeffrey Albers W.	Director	Sale of securities on an exchange or to another person at price $ 81.16 per share.	25 Jan 2024	6,086	194,964 (0%)	0%	81.2	493,940	Common Stock
Albers Jeffrey W.	Director	Sale of securities on an exchange or to another person at price $ 82.76 per share.	25 Jan 2024	7,924	176,150 (0%)	0%	82.8	655,790	Common Stock
Albers Jeffrey W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jan 2024	10,000	2,496	-		-	Stock Option (Right to Buy)
W. Jeffrey Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	25 Jan 2024	15,000	191,050 (0%)	0%	1.9	28,050	Common Stock
Jeffrey Albers W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	25 Jan 2024	10,000	201,050 (0%)	0%	15.0	150,100	Common Stock
Hurley Ariel	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Dec 2023	714	0	-		-	Stock Option (Right to Buy)
Hurley Ariel	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 90.00 per share.	22 Dec 2023	714	14,324 (0%)	0%	90	64,260	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share.	22 Dec 2023	714	15,038 (0%)	0%	8.8	6,283	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 84.35 per share.	15 Dec 2023	260	14,324 (0%)	0%	84.4	21,931	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 84.35 per share.	15 Dec 2023	1,827	14,584 (0%)	0%	84.3	154,107	Common Stock
Hurley Ariel	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	15 Dec 2023	1,827	16,411 (0%)	0%	1.9	3,416	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	15 Dec 2023	1,827	16,411 (0%)	0%	1.9	3,416	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 84.35 per share.	15 Dec 2023	1,827	14,584 (0%)	0%	84.3	154,107	Common Stock
Hurley Ariel	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Dec 2023	3,654	0	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	13 Dec 2023	261	31,439 (0%)	0%	1.9	488	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Dec 2023	261	0	-		-	Stock Option (Right to Buy)
Albers Jeffrey W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Dec 2023	5,000	150,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	11 Dec 2023	5,000	181,050 (0%)	0%	36.1	180,250	Common Stock
W. Jeffrey Albers	Director	Sale of securities on an exchange or to another person at price $ 79.07 per share.	11 Dec 2023	5,000	176,050 (0%)	0%	79.1	395,350	Common Stock
Christopher Murray K.	CHIEF TECHNICAL OPERATIONS		07 Dec 2023	5,000	13,000	-		-	Stock Option (Right to Buy)
K. Christopher Murray	CHIEF TECHNICAL OPERATIONS		07 Dec 2023	5,000	29,495 (0%)	0%	54.1	270,650	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		07 Dec 2023	5,000	24,495 (0%)	0%	75	375,000	Common Stock
K. Christopher Murray	CHIEF TECHNICAL OPERATIONS		04 Dec 2023	600	24,495 (0%)	0%	71.4	42,858	Common Stock
Albers W. Jeffrey	Director	Sale of securities on an exchange or to another person at price $ 70.55 per share.	30 Nov 2023	5,000	176,050 (0%)	0%	70.6	352,750	Common Stock
Albers Jeffrey W.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Nov 2023	5,000	155,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	30 Nov 2023	5,000	181,050 (0%)	0%	36.1	180,250	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 67.25 per share.	24 Nov 2023	7,964	183,086 (0%)	0%	67.3	535,579	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Nov 2023	15,000	30,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 67.81 per share.	24 Nov 2023	7,036	176,050 (0%)	0%	67.8	477,111	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	24 Nov 2023	15,000	191,050 (0%)	0%	1.9	28,050	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	01 Nov 2023	1,485	177,535 (0%)	0%	36.0	53,534	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2023	1,485	160,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2023	4,634	161,485	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2023	3,881	166,119	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 60.13 per share.	01 Nov 2023	1,485	176,050 (0%)	0%	60.1	89,293	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 61.05 per share.	01 Nov 2023	59	176,050 (0%)	0%	61.1	3,602	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 60.36 per share.	01 Nov 2023	4,575	176,109 (0%)	0%	60.4	276,147	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	01 Nov 2023	4,634	180,684 (0%)	0%	36.1	167,056	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 60.02 per share.	01 Nov 2023	3,881	176,050 (0%)	0%	60.0	232,938	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.05 per share.	01 Nov 2023	3,881	179,931 (0%)	0%	36.0	139,910	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		26 Oct 2023	600	25,095 (0%)	0%	56.4	33,840	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 48.06 per share.	04 Oct 2023	3,769	62,080 (0%)	0%	48.1	181,138	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 Sep 2023	18,102	51,971	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 50.17 per share.	27 Sep 2023	6,898	176,050 (0%)	0%	50.2	346,073	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	27 Sep 2023	6,898	182,948 (0%)	0%	1.9	12,899	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 50.50 per share.	27 Sep 2023	400	176,050 (0%)	0%	50.5	20,200	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 49.93 per share.	27 Sep 2023	12,102	176,450 (0%)	0%	49.9	604,253	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	27 Sep 2023	18,102	194,152 (0%)	0%	1.9	33,851	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 48.84 per share.	27 Sep 2023	5,600	188,552 (0%)	0%	48.8	273,504	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 Sep 2023	6,898	45,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	24 Aug 2023	10,000	186,050 (0%)	0%	1.9	18,700	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Aug 2023	15,000	80,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 50.16 per share.	24 Aug 2023	10,000	176,050 (0%)	0%	50.2	501,600	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	24 Aug 2023	15,000	191,050 (0%)	0%	1.9	28,050	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 49.57 per share.	24 Aug 2023	15,000	176,050 (0%)	0%	49.6	743,550	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Aug 2023	10,000	70,073	-		-	Stock Option (Right to Buy)
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	71,918 (0%)	0%		0	Common Stock
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	16,012 (0%)	0%		0	Common Stock
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	11,012 (0%)	0%		0	Common Stock
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	8,600 (0%)	0%		0	Common Stock
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	176,050 (0%)	0%		0	Common Stock
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	11,012 (0%)	0%		0	Common Stock
Nicholas Lydon	Director		21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Nicholas Lydon	Director		21 Jun 2023	2,600	55,784 (0%)	0%		0	Common Stock
Habib J. Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	6,500 (0%)	0%		0	Common Stock
Habib J. Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	2,600	6,500 (0%)	0%		0	Common Stock
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2023	5,300	5,300	-		-	Stock Option (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 52.05 per share.	05 Jun 2023	1,404	36,878 (0%)	0%	52.0	73,078	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 52.06 per share.	05 Jun 2023	2,307	38,117 (0%)	0%	52.1	120,102	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2023	1,600	1,600	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 87.28 per share.	15 Mar 2023	2,949	14,913 (0%)	0%	87.3	257,389	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 90.00 per share.	15 Mar 2023	800	17,862 (0%)	0%	90	72,000	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	15 Mar 2023	800	18,662 (0%)	0%	15.0	12,008	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 87.28 per share.	15 Mar 2023	800	17,862 (0%)	0%	87.3	69,824	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	15 Mar 2023	800	18,662 (0%)	0%	15.0	12,008	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 44.27 per share.	06 Mar 2023	319	173,450 (0%)	0%	44.3	14,122	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	9,474	173,769 (0%)	0%	45.7	433,151	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 44.48 per share.	06 Mar 2023	96	48,523 (0%)	0%	44.5	4,270	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	2,911	48,619 (0%)	0%	45.7	133,091	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 44.65 per share.	06 Mar 2023	212	125,641 (0%)	0%	44.7	9,466	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	6,428	125,853 (0%)	0%	45.7	293,888	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	3,216	52,772 (0%)	0%	45.7	147,036	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 44.41 per share.	06 Mar 2023	106	52,666 (0%)	0%	44.4	4,707	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		06 Mar 2023	1,829	25,741 (0%)	0%	45.7	83,604	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		06 Mar 2023	46	25,695 (0%)	0%	44.3	2,038	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	2,960	55,475 (0%)	0%	45.7	135,331	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 44.28 per share.	06 Mar 2023	99	55,376 (0%)	0%	44.3	4,384	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	1,091	14,210 (0%)	0%	45.7	49,881	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 44.40 per share.	06 Mar 2023	35	14,175 (0%)	0%	44.4	1,554	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 45.71 per share.	06 Mar 2023	3,084	50,252 (0%)	0%	45.7	140,970	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 44.30 per share.	06 Mar 2023	74	50,178 (0%)	0%	44.3	3,278	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 44.37 per share.	06 Mar 2023	63	65,849 (0%)	0%	44.4	2,795	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	1,885	65,912 (0%)	0%	45.7	86,182	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	1,466	38,330 (0%)	0%	45.7	67,026	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 44.77 per share.	06 Mar 2023	48	38,282 (0%)	0%	44.8	2,149	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	1,622	31,232 (0%)	0%	45.7	74,158	Common Stock
Philina Lee	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 44.41 per share.	06 Mar 2023	54	31,178 (0%)	0%	44.4	2,398	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 45.72 per share.	06 Mar 2023	736	40,449 (0%)	0%	45.7	33,650	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 44.80 per share.	06 Mar 2023	25	40,424 (0%)	0%	44.8	1,120	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Option (Right to Buy)
Michael Landsittel	CHIEF FINANCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	51,530 (0%)	0%		0	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	80,000	80,000	-		-	Stock Option (Right to Buy)
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	40,000	132,281 (0%)	0%		0	Common Stock
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Option (Right to Buy)
Tracey L. McCain	EVP AND CHIEF LEGAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	55,988 (0%)	0%		0	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		01 Mar 2023	8,750	27,570 (0%)	0%		0	Common Stock
Christopher K. Murray	CHIEF TECHNICAL OPERATIONS		01 Mar 2023	17,500	17,500	-		-	Stock Option (Right to Buy)
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	30,000	30,000	-		-	Stock Option (Right to Buy)
Christina Rossi	CHIEF OPERATING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	15,000	58,435 (0%)	0%		0	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	10,850	10,850	-		-	Stock Option (Right to Buy)
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	5,425	15,301 (0%)	0%		0	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Option (Right to Buy)
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	53,336 (0%)	0%		0	Common Stock
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	15,000	67,797 (0%)	0%		0	Common Stock
Fouad Namouni	PRESIDENT, R & D	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	30,000	30,000	-		-	Stock Option (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	39,796 (0%)	0%		0	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Options (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Option (Right to Buy)
Philina Lee	CHIEF COMMERCIAL OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	32,854 (0%)	0%		0	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	12,500	41,185 (0%)	0%		0	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2023	25,000	25,000	-		-	Stock Option (Right to Buy)
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	06 Jan 2023	3,900	3,900 (0%)	0%		0	Common Stock
John Tsai	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	06 Jan 2023	7,950	7,950	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 50.09 per share.	05 Dec 2022	20,000	183,243 (0%)	0%	50.1	1,001,800	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Dec 2022	10,000	95,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Dec 2022	10,000	20,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	05 Dec 2022	10,000	193,243 (0%)	0%	1.9	18,700	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	05 Dec 2022	10,000	203,243 (0%)	0%	15.0	150,100	Common Stock
Kathryn Haviland	CHIEF EXECUTIVE OFFICER	Purchase of securities on an exchange or from another person at price $ 43.98 per share.	03 Nov 2022	1,100	92,281 (0%)	0%	44.0	48,378	Common Stock
Christina Rossi	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 45.24 per share.	03 Nov 2022	533	43,435 (0%)	0%	45.2	24,113	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 67.30 per share.	04 Oct 2022	3,477	52,797 (0%)	0%	67.3	234,002	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 70.02 per share.	19 Aug 2022	1,590	183,243 (0%)	0%	70.0	111,332	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Aug 2022	8,410	30,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Aug 2022	1,590	38,410	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 71.30 per share.	19 Aug 2022	662	183,243 (0%)	0%	71.3	47,201	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 70.47 per share.	19 Aug 2022	7,748	183,905 (0%)	0%	70.5	546,002	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	19 Aug 2022	8,410	191,653 (0%)	0%	15.0	126,234	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	19 Aug 2022	1,590	184,833 (0%)	0%	15.0	23,866	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	16 Aug 2022	10,000	203,243 (0%)	0%	15.0	150,100	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2022	10,000	40,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2022	10,000	105,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 69.52 per share.	16 Aug 2022	293	183,243 (0%)	0%	69.5	20,369	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 68.62 per share.	16 Aug 2022	12,477	183,536 (0%)	0%	68.6	856,172	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 68.01 per share.	16 Aug 2022	7,230	196,013 (0%)	0%	68.0	491,712	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	16 Aug 2022	10,000	193,243 (0%)	0%	1.9	18,700	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	08 Aug 2022	2,830	193,243 (0%)	0%	1.9	5,292	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Aug 2022	2,830	115,073	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Aug 2022	7,170	0	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 70.07 per share.	08 Aug 2022	10,000	183,243 (0%)	0%	70.1	700,700	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share.	08 Aug 2022	7,170	190,413 (0%)	0%	8.8	63,096	Common Stock
Christopher K. Murray	SVP, TECHNICAL OPERATIONS		04 Aug 2022	2,500	18,820 (0%)	0%	65	162,500	Common Stock
Christopher K. Murray	SVP, TECHNICAL OPERATIONS		04 Aug 2022	2,500	21,320 (0%)	0%	60.4	151,100	Common Stock
Habib J. Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Jun 2022	3,900	3,900 (0%)	0%		0	Common Stock
Habib J. Dable	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Jun 2022	7,950	7,950	-		-	Stock Option (Right to Buy)
Alexis A. Borisy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	69,318 (0%)	0%		0	Common Stock
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	13,412 (0%)	0%		0	Common Stock
Mark Alan Goldberg	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	8,412 (0%)	0%		0	Common Stock
Lynn Seely	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	6,000 (0%)	0%		0	Common Stock
Daniella Beckman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	8,412 (0%)	0%		0	Common Stock
Lonnel Coats	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
George D. Demetri	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
George D. Demetri	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2022	2,600	8,412 (0%)	0%		0	Common Stock
George D. Demetri	Director	Sale of securities on an exchange or to another person at price $ 58.60 per share.	21 Jun 2022	10	5,812 (0%)	0%	58.6	586	Common Stock
George D. Demetri	Director	Purchase of securities on an exchange or from another person at price $ 82.70 per share.	21 Jun 2022	10	5,822 (0%)	0%	82.7	827	Common Stock
Nicholas Lydon	Director		21 Jun 2022	2,600	53,184 (0%)	0%		0	Common Stock
Nicholas Lydon	Director		21 Jun 2022	5,300	5,300	-		-	Stock Option (Right to Buy)
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 59.76 per share.	06 Jun 2022	1,220	30,451 (0%)	0%	59.8	72,907	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 60.00 per share.	06 Jun 2022	3,155	27,296 (0%)	0%	60	189,300	Common Stock
Percy H. Carter	CHIEF SCIENTIFIC OFFICER	Sale of securities on an exchange or to another person at price $ 59.76 per share.	06 Jun 2022	1,908	28,685 (0%)	0%	59.8	114,022	Common Stock
Nicholas Lydon	Director		23 May 2022	10,909	0	-		-	Stock Option (Right to Buy)
Nicholas Lydon	Director		23 May 2022	10,909	50,584 (0%)	0%	19.5	213,053	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 54.48 per share.	16 May 2022	1,900	201,343 (0%)	0%	54.5	103,512	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	16 May 2022	10,000	203,243 (0%)	0%	15.0	150,100	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	16 May 2022	10,000	193,243 (0%)	0%	1.9	18,700	Common Stock
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 May 2022	10,000	50,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 May 2022	10,000	117,903	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 56.21 per share.	16 May 2022	12,758	183,243 (0%)	0%	56.2	717,127	Common Stock
Jeffrey W. Albers	Director	Sale of securities on an exchange or to another person at price $ 55.63 per share.	16 May 2022	5,342	196,001 (0%)	0%	55.6	297,175	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	06 Apr 2022	5,000	188,243 (0%)	0%	15.0	75,050	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	06 Apr 2022	5,000	60,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 70.11 per share.	06 Apr 2022	5,000	183,243 (0%)	0%	70.1	350,550	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 60.00 per share.	16 Mar 2022	2,219	31,671 (0%)	0%	60	133,140	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 57.15 per share.	10 Mar 2022	2,339	9,616 (0%)	0%	57.2	133,674	Common Stock
Fouad Namouni	PRESIDENT, R & D	Sale of securities on an exchange or to another person at price $ 56.19 per share.	07 Mar 2022	1,047	56,274 (0%)	0%	56.2	58,831	Common Stock
Becker Hewes	CHIEF MEDICAL OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	07 Mar 2022	1,047	33,890 (0%)	0%	56.2	58,831	Common Stock
Mark Alan Goldberg	Director	Purchase of securities on an exchange or from another person at price $ 59.98 per share.	03 Mar 2022	5,000	10,812 (0%)	0%	60.0	299,900	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 60.28 per share.	03 Mar 2022	7,862	188,086 (0%)	0%	60.3	473,921	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2022	12,500	65,000	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2022	7,500	127,903	-		-	Stock Option (Right to Buy)
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	4,843	183,243 (0%)	0%	56.2	272,128	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 59.43 per share.	03 Mar 2022	1,400	188,086 (0%)	0%	59.4	83,202	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 58.28 per share.	03 Mar 2022	4,100	189,486 (0%)	0%	58.3	238,948	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 57.66 per share.	03 Mar 2022	4,445	193,586 (0%)	0%	57.7	256,299	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Sale of securities on an exchange or to another person at price $ 56.61 per share.	03 Mar 2022	10,055	198,031 (0%)	0%	56.6	569,214	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.01 per share.	03 Mar 2022	12,500	208,086 (0%)	0%	15.0	187,625	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.87 per share.	03 Mar 2022	7,500	195,586 (0%)	0%	1.9	14,025	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	1,047	39,030 (0%)	0%	56.2	58,831	Common Stock
Michael Landsittel	CHIEF FINANCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 60.27 per share.	03 Mar 2022	1,328	40,077 (0%)	0%	60.3	80,039	Common Stock
Kathryn Haviland	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 56.18 per share.	03 Mar 2022	1,048	91,181 (0%)	0%	56.2	58,877	Common Stock
Kathryn Haviland	CHIEF OPERATING OFFICER	Sale of securities on an exchange or to another person at price $ 60.27 per share.	03 Mar 2022	1,719	92,229 (0%)	0%	60.3	103,604	Common Stock
Tracey McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	1,047	43,227 (0%)	0%	56.2	58,831	Common Stock
Tracey McCain	EVP AND CHIEF LEGAL OFFICER	Sale of securities on an exchange or to another person at price $ 60.28 per share.	03 Mar 2022	1,667	44,274 (0%)	0%	60.3	100,487	Common Stock
Christopher K. Murray	SVP, TECHNICAL OPERATIONS		03 Mar 2022	502	23,820 (0%)	0%	56.2	28,207	Common Stock
Christopher K. Murray	SVP, TECHNICAL OPERATIONS		03 Mar 2022	1,066	24,322 (0%)	0%	60.3	64,248	Common Stock
Christina Rossi	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	1,047	44,479 (0%)	0%	56.2	58,831	Common Stock
Christina Rossi	CHIEF COMMERCIAL OFFICER	Sale of securities on an exchange or to another person at price $ 60.28 per share.	03 Mar 2022	1,197	45,526 (0%)	0%	60.3	72,155	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	256	11,955 (0%)	0%	56.2	14,385	Common Stock
Ariel Hurley	PRINCIPAL ACCOUNTING OFFICER	Sale of securities on an exchange or to another person at price $ 60.27 per share.	03 Mar 2022	761	12,211 (0%)	0%	60.3	45,865	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 56.19 per share.	03 Mar 2022	1,047	40,836 (0%)	0%	56.2	58,831	Common Stock
Debra Durso-Bumpus	CHIEF PEOPLE OFFICER	Sale of securities on an exchange or to another person at price $ 60.27 per share.	03 Mar 2022	1,491	41,883 (0%)	0%	60.3	89,863	Common Stock
Jeffrey W. Albers	Director, CEO AND PRESIDENT	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2022	7,500	195,948 (0%)	0%		0	Common Stock

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

Insider Trading disclosures for Blueprint Medicines Corp

The latest disclosure was made by Christina Rossi in Blueprint Medicines Corp where a trade of 1,172 Common Stock done at an average price of $128.3 was reported to US exchanges on July 3, 2025.

Screeners based on Insider Trading and SAST parameters